>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
<1.0 EU per 1 μg of the protein by the LAL method.
19 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
20-22 kDa, reducing conditions
Read Publication using 1708-PI in the following applications:
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Alternate Names for Recombinant Human Lipocalin-1 Protein, CF
lipocalin 1 (tear prealbumin)
lipocalin 1-like 2
TPVon Ebner gland protein
VEGPlipocalin 1 (protein migrating faster than albumin, tear prealbumin)
Lipocalin-1, also known as tear prealbumin or von Ebner’s gland protein (VEGP), is encoded by the LCN1 gene (1-3). It is a member of the Lipocalin superfamily that binds many different classes of lipophylic chemicals (4). Lipocalin-1 contains three sequence motifs similar to the cystatins, a superfamily of cysteine protease inhibitors (5). In fact, it has been suggested that Lipocalin-1 is a physiological inhibitor of cysteine proteases and plays a role in the control of inflammatory processes in oral and ocular tissues (5). Recombinant Human Lipocalin-1 corresponds to the mature and secreted protein. It is a weak inhibitor of cysteine proteases such as cathepsin V, which is similar to recombinant human Cystatin S (Catalog # 1296-PI).
Redl, B. et al. (1992) J. Biol. Chem. 267:20282.
Blaker, M. et al. (1993) Biochim. Biophys. Acta 1172:131.
Lassagne, H. and A.M. Gachon (1993) Exp. Eye Res. 56:605.
Redl, B. et al. (2000) Biochim. Biophys. Acta 1482:241.
van’t Hof, W. et al. (1997) J. Biol. Chem. 272:1837.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.