PTH1R/PTHR1 Antibody (542407) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 542407
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

PTH1R/PTHR1 Antibody (542407) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human PTHR1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PTH1R/PTHR1 Antibody (542407) [Alexa Fluor™ Plus 647]

• MGC138426
• parathyroid hormone 1 receptorMGC138452
• parathyroid hormone/parathyroid hormone-related peptide receptor
• parathyroid hormone/parathyroid hormone-related protein receptor
• PFE
• PTH/PTHr receptor
• PTH/PTHrP type I receptor
• PTH1 receptor
• PTH1R
• PTHR
• PTHR1
• PTHRPTHR1parathyroid hormone receptor 1
• seven transmembrane helix receptor

Background

PTH1R (Parathyroid hormone receptor # 1; also PTH/PTHr receptor) is a predicted 66-68 kDa member of the G-protein coupled receptor family # 2. It is expressed on a variety of cell types, including hepatocytes, renal epithelium, smooth muscle cells, and osteoblasts plus chondrocytes. PTH1R is a receptor for both PTH and PTHrP, and PTH binding promotes Ca⁺⁺-release from bone, mediated by osteoclast formation. Mature human PTH1R is a 7-transmembrane glycoprotein 567 amino acids (aa) in length. It contains a long, ligand-binding N-terminal extracellular region (aa 27-188) and a 130 aa cytoplasmic C-terminal domain. Single aa changes such as Gly121Glu, Ala122Thr and Arg255His can impair PTH1R signaling. Over aa 1-189, human PTH1R shares 88% aa identity with mouse PTH1R.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.