Pin1 Antibody (257417) [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB, IHC, IP, ICC/IF
• Clone: 257417
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Pin1 Antibody (257417) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Pin1
  Ala2-Glu163
  Accession # Q13526
• Specificity: Detects human and mouse Pin1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Pin1 Antibody (257417) [Alexa Fluor® 350]

• dod
• EC 5.2.1.8
• peptidylprolyl cis/trans isomerase, NIMA-interacting 1
• peptidyl-prolyl cis/trans isomerase, NIMA-interacting
• peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
• Peptidyl-prolyl cis-trans isomerase Pin1
• Pin1
• PPIase Pin1
• prolyl isomerase
• protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
• protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
• Rotamase Pin1
• UBL5

Background

Pin1 is a peptidyl-prolyl isomerase (PPI) that targets phosphorylated Ser or Thr residues followed by a Pro (S/T-P). Isomerization of phosphorylated Ser or Thr residues may alter protein confirmation and, subsequently, modify activity. Pin1 is overexpressed in many human breast cancers, and has been shown to modify numerous proteins including p53,NF-kappa B, c-Jun, cyclin D1, and beta -catenin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.