PD-ECGF/Thymidine Phosphorylase Antibody (P-GF.44C)

Immunohistochemistry-Paraffin: PD-ECGF/Thymidine Phosphorylase Antibody (P-GF.44C) [NBP2-26443] - Formalin fixed paraffin embedded colon carcinoma stained with Thymidine phosphorylase antibody (NBP2-26443).

Product Discontinued

PD-ECGF/Thymidine Phosphorylase Antibody (P-GF.44C) Summary

• Immunogen: BALB/C mice were injected with a recombinant full length human thymidine phosphorylase (TP/PD-ECGF) protein.
• Localization: Cytoplasmic, Nuclear
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TYMP
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:25-1:75
  • Western Blot 1:50 - 1:100

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: None, containing less than 0.1% sodium azide
• Preservative: 0.09% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for PD-ECGF/Thymidine Phosphorylase Antibody (P-GF.44C)

• dThdPase
• EC 2.4.2
• EC 2.4.2.4
• ECGF
• ECGF1
• ECGF1TP
• endothelial cell growth factor 1 (platelet-derived)
• Gliostatin
• hPD-ECGF
• MEDPS1
• MNGIE
• MTDPS1
• PDECGF
• PD-ECGF
• Platelet-derived endothelial cell growth factor
• TdRPase
• Thymidine Phosphorylase
• TPase
• TYMP

Background

Principal Names: Endothelial cell growth factor 1 (platelet-derived) Official Gene Symbol: ECGF1 Gene ID: 1890 (Human) Gene Map Locus: 22q13; 22q13.33 (Human) Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an enzyme with a relative molecular mass of about 45,000 and angiogenic and cell motility properties. Moreover, it is involved in the transformation of fluoropyrimidines into active cytotoxic metabolites. It has a highly restricted target cell specificity acting only on endothelial cells, promoting its activity in vitro and chemotactic activity in vitro. The gene contains 10 exons spanning more than 4.3 kb. Mutations in the gene cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TYMP