PC6 Antibody

• Reactivity: Hu
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

PC6 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence PDGSYQDTKKNLCRK corresponding to internal region according to NP_006191.2.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PCSK5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments in lysates of K562 and MOLT4 gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PC6 Antibody

• EC 3.4.21
• EC 3.4.21.-
• EC 3.4.21.61
• EC 3.4.21.75
• FLJ11149
• FLJ16215
• hPC6
• PC5PC6A
• PC6prohormone convertase 5
• Proprotein convertase 5
• Proprotein convertase 6
• proprotein convertase PC5
• proprotein convertase subtilisin/kexin type 5
• protease PC6
• SPC6
• Subtilisin/kexin-like protease PC5

Background

PC6 is encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PC6 Antibody (NBP1-46106)(1)

Publication using NBP1-46106

• Jin W, Wang X, Millar JS et al. Hepatic proprotein convertases modulate HDL metabolism Cell Metab 2007-08-01 [PMID: 17681148]

Bioinformatics

• Gene Symbol: PCSK5
• Entrez:
  • 5125(Human)
• Uniprot:
  • NP_006191.2(Human)