Orexin R2/HCRTR2 Antibody (456738) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 456738
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Orexin R2/HCRTR2 Antibody (456738) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Orexin R2/HCRTR2. Stains human Orexin R2/HCRTR2 transfectants but not irrelevant transfectants.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Orexin R2/HCRTR2 Antibody (456738) [Alexa Fluor™ Plus 647]

• HCRTR2
• hypocretin (orexin) receptor 2
• Hypocretin receptor type 2
• Orexin R2
• Orexin Receptor 2
• orexin receptor type 2
• OrexinR2
• OX2R
• Ox-2-R
• ox2-R

Background

Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. It also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.