Orexin R2/HCRTR2 Antibody (456723) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 456723
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Orexin R2/HCRTR2 Antibody (456723) [Alexa Fluor® 488] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human Orexin R2/HCRTR2
  Met1-Trp444
  Accession # AAC39602
• Specificity: Detects human Orexin R2/HCRTR2. In flow cytometry, stains human Orexin R2/HCRTR2 transfectants but not irrelevant transfectants.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Orexin R2/HCRTR2 Antibody (456723) [Alexa Fluor® 488]

• HCRTR2
• hypocretin (orexin) receptor 2
• Hypocretin receptor type 2
• Orexin R2
• Orexin Receptor 2
• orexin receptor type 2
• OrexinR2
• OX2R
• Ox-2-R
• Ox2-R

Background

Orexin R2 (Orexin Receptor 2), also known as HCRTR2 (Hypocretin Receptor 2) or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of Orexin Rs/HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. It also influences reward circuits involving food or addictive drugs. The extracellular portions of human Orexin R2/HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat Orexin R2/HCRTR2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.