MRGX2 Antibody (477533) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 477533
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

MRGX2 Antibody (477533) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human MRGX2. Stains human MRGX2 transfectants but not irrelevant transfectants.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MRGX2 Antibody (477533) [Alexa Fluor™ Plus 647]

• MAS-related GPR, member X2
• mas-related G-protein coupled receptor member X2
• MRGPRX2
• MRGX2
• MRGX2G protein-coupled receptor MRGX2

Background

MRGX2 (MAS-related GPR, member X2) is a 330 amino acid (aa) G-protein coupled 7-transmembrane protein that is selectively expressed in small-diameter sensory neurons of dorsal root ganglia. Human MRGX shares 41‑52% aa identity with three other primate MRGX proteins. Binding of ligands such as cortistatin, proadrenomedullin peptides (PAMP-12 and –20) and basic peptides (substance P, neuropeptide Y) to MRGX2 can activate Gq or Gi regulated pathways. MRGX2 is thought to influence nociception and promote adrenal gland catecholamine secretion and IgE-independent mast cell degranulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.