MMADHC Antibody (OTI1G4) [Janelia Fluor® 525]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI1G4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 525

MMADHC Antibody (OTI1G4) [Janelia Fluor® 525] Summary

• Immunogen: Human recombinant protein fragment corresponding to amino acids 39-296 of human MMADHC (NP_056517) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MMADHC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MMADHC Antibody (OTI1G4) [Janelia Fluor® 525]

• cblD
• chromosome 2 open reading frame 25
• methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
• mitochondrial
• protein C2orf25, mitochondrial

Background

MMADHC encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MMADHC