Kallikrein 5 Antibody (193318) [Alexa Fluor™ Plus 488]

• Clone: 193318
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

Kallikrein 5 Antibody (193318) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Kallikrein 5 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Kallikrein 3, rhKallikrein 4, rhKallikrein 8, or rhKallikrein 11 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Human tissue Kallikrein 5 (hK5, also known as stratum corneum tryptic enzyme) is a serine protease of the human tissue Kallikrein gene family (1, 2). The deduced amino acid sequence of human Kallikrein 5 consists of a signal peptide (Met1 to Gly22), a pro region (Val23 to Arg66) and a mature/active enzyme (Ile67 to Ser293). Kallikrein 5 is expressed mainly in skin, breast, brain and testis and to a lesser extent in many other tissues (3). Kallikrein 5 overexpression is an indicator of poor prognosis in ovarian cancer (4). Kallikrein 5 is a candidate physiological activator of Kallikrein 7 in the stratum corneum (5).

1. Brattsand, M. and T. Egelrud (1999) J. Biol. Chem. 274:30033.
2. Yousef, G.M. et al. (1999) Anticancer Res. 19:2843.
3. Yousef, G.M. and E.P. Diamandis (2001) Endocrine Rev. 22:184.
4. Yousef, G.M. and E.P. Diamandis (1999) J. Biol. Chem. 274:37511.
5. Kim, H. et al. (2001) Br. J. Cancer 84:643.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.