IA-2/PTPRN Antibody

Western Blot: IA-2/PTPRN Antibody [H00005798-B02P] - Analysis of PTPRN expression in transfected 293T cell line by PTPRN polyclonal antibody. Lane 1: PTPRN transfected lysate(104.5 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

IA-2/PTPRN Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: PTPRN (AAH70053.1, 1 a.a. - 950 a.a.) full-length human protein. MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQNVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ
• Specificity: Reacts with protein tyrosine phosphatase, receptor type, N.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: PTPRN
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for IA-2/PTPRN Antibody

• CA 512
• EC 3.1.3.48
• FLJ16131
• IA2
• IA-2
• IA-2/PTP
• ICA 512
• ICA3
• ICA512
• islet cell antigen 2
• Islet cell antigen 512
• Islet cell autoantigen 3
• protein tyrosine phosphatase, receptor type, N
• protein tyrosine phosphatase-like N
• PTP IA-2
• PTPRN
• receptor-type tyrosine-protein phosphatase-like N
• R-PTP-N

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IA-2/PTPRN Antibody (H00005798-B02P)(1)

Publication using H00005798-B02P

• Paramithiotis E, Prentki M, Rabasa-lhoret R et al. Type 2 Diabetes Biomarkers and Uses Thereof. United States Patent Application 2015-11-19

Bioinformatics

• Gene Symbol: PTPRN
• Entrez:
  • 5798(Human)
• Uniprot:
  • AAH70053.1(Human)