IA-2/PTPRN Antibody (815811) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 815811
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

IA-2/PTPRN Antibody (815811) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human IA-2/PTPRN
  Val35-Arg575
  Accession # Q16849
• Specificity: Detects human IA-2/PTPRN in ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IA-2/PTPRN Antibody (815811) [Alexa Fluor® 647]

• CA 512
• EC 3.1.3.48
• FLJ16131
• IA2
• IA-2
• IA-2/PTP
• ICA 512
• ICA3
• ICA512
• islet cell antigen 2
• Islet cell antigen 512
• Islet cell autoantigen 3
• protein tyrosine phosphatase, receptor type, N
• protein tyrosine phosphatase-like N
• PTP IA-2
• PTPRN
• receptor-type tyrosine-protein phosphatase-like N
• R-PTP-N

Background

IA-2 (insulinoma-assocated protein 2), also called PTPRN (protein tyrosine phosphatase-like N) and ICA512 (islet cell antigen 512), is a 130 kDa member of the receptor tyrosine phosphatase family of type I transmembrane enzymes. It is not active as a phosphatase but acts an autoantigen in type I (insulin-dependent) diabetes. It is mainly expressed in neuroendocrine cells types within pancreatic islets, adrenal medulla, pituitary, and the central nervous system, and is present within membranes of regulated secretory granules. It is induced by glucose and insulin in the pancreas and is thought to contribute to the growth of beta cells. Cleavage at a furin-like site at amino acid (aa) 448 creates a 60-66 kDa transmembrane fragment. Within the region used as an immunogen, human IA-2 shares 80% aa sequence identity with mouse and rat IA-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.