GRK3 Antibody (497007) [PE]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clone: 497007
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

GRK3 Antibody (497007) [PE] Summary

• Immunogen: E. coli-derived recombinant human GRK3
  Pro469-Leu688
  Accession # P35626
• Specificity: Detects human GRK3 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for GRK3 Antibody (497007) [PE]

• ADRBK2
• adrenergic, beta, receptor kinase 2
• BARK2
• BARK2beta-adrenergic receptor kinase 2
• Beta-ARK-2
• EC 2.7.11
• EC 2.7.11.15
• G-protein-coupled receptor kinase 3
• GRK3
• GRK3Beta-ARK-2

Background

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second essenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.