GPR98 Antibody

Immunohistochemistry-Paraffin: GPR98 Antibody [NLS1729] - Anti-GPR98 / VLGR1 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: GPR98 Antibody [NLS1729] - Analysis of anti-GPR98 / VLGR1 antibody with human kidney, renal tubules.

Immunohistochemistry-Paraffin: GPR98 Antibody [NLS1729] - Analysis of anti-GPR98 / VLGR1 antibody with human brain, cortex.

Immunohistochemistry-Paraffin: GPR98 Antibody [NLS1729] - Analysis of human Ovary, Carcinoma.

Immunohistochemistry-Paraffin: GPR98 Antibody [NLS1729] - Analysis of human Skin, Melanoma.

Product Discontinued

GPR98 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GPR98.
• Localization: Cell Membrane
• Specificity: Human GPR98. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%), Monkey (95%), Bat (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GPR98
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 - 26 ug/ml
  • Western Blot 1:1000 - 1:10000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Hamster (89%), Mouse (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GPR98 Antibody

• FEB4
• G protein-coupled receptor 98
• MASS1
• USH2B
• USH2C
• VLGR1
• VLGR1b

Background

GPR98, also known as Very Large G Protein-Coupled Receptor-1 (VLGR1), is an Orphan-A GPCR with an unknown ligand. VLGR1 consists of three expressed isoforms. VLGR1 has a large ectodomain containing multiple CALX-beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. VLGR1b, which is the only form expressed in mouse, is apparently the largest known cell-surface protein with an ectodomain containing 35 CALX- repeats and a pentraxin homology domain. The MASS1 gene, which is a fragment of the very large G-protein-coupled receptor VLGR1, is mutated in the Frings mouse model of audiogenic epilepsy. VLGR1 has been reported to be widely expressed in normal solid tissues. ESTs have been isolated from human adrenal, brain, colon, eye, kidney, nerve, and testis libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GPR98
• Entrez:
  • 84059(Human)
• Uniprot:
  • Q8WXG9(Human)