Reactivity | HuSpecies Glossary |
Applications | Flow |
Clone | 206420 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Alexa Fluor 594 |
Conjugate | Catalog # | Availability | Size | Price |
---|---|---|---|---|
Alexa Fluor 350 | FAB7977U-100UG | |||
Alexa Fluor 405 | FAB7977V-100UG | |||
Alexa Fluor 488 | FAB7977G-100UG | |||
Alexa Fluor 647 | FAB7977R-100UG | |||
Alexa Fluor 700 | FAB7977N-100UG | |||
Alexa Fluor 750 | FAB7977S-100UG | |||
Phycoerythrin | FAB7977P-100 | |||
Unconjugated | MAB7977-100 | |||
Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human GPR64 Leu38-Asn64, Glu68-Thr553 Accession # NP_001073328 |
Specificity | Detects human GPR64 transfectants in cell-based ELISA and Flow Cytometry. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Mouse |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Protect from light. Do not freeze.
|
Buffer | Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide. |
GPR64 (G-Protein coupled Receptor 64; also HE6) is a 110 kDa (predicted) member of the B class of GCPRs. Within this class GPR64 belongs to a Large N-termini family-B 7-transmembrane (LNB-7TM) subclass of receptors (also known as adhesion-GCPRs). GPR64 has restricted expression, being found in stereocilia cell membranes of epididymal caput epithelial cells and, to a limited extent, on osteoblasts. The function of GPR64 is somewhat unclear, but in the epididymis, it may be involved in fluid transport. Mature human GPR64 is a 980 amino acid (aa) 7-TM glycoprotein (SwissProt Q8IZP9). It contains an extended extracellular N-teminus (aa 38-627), seven consecutive TM segments (aa 628-878) and a C-terminal cytoplasmic tail (aa 879-1010). The extended extracellular region possesses a juxtamembrane GPS domain (aa 567-618) that serves as a proteolytic cleavage site. Enzymatic activity here generates a 180 kDa soluble form that stays associated with a 40 kDa membrane-embedded fragment. Notably, isolation of the membrane fragment gives rise to oligomers that run at > 250 kDa in SDS-PAGE. There are multiple splice variants. The one used for immunization to generate this antibody contains a deletion of aa 88-101 (RefSeq NP_001073328). Four other splice forms show single block deletions of aa 65-67, 51-66, 52-75, and 906-956, respectively. Three others possesses aa substitutions; a 20 aa block for aa 52-101, and a common 12 aa block that can substitute for either aa 68-101 or aa 52-101. Over aa 38-64 and 68-553 of RefSeq NP_001073328, human and mouse GPR64 share 69% aa sequence identity.
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 350 | FAB7977U | |
Alexa Fluor 405 | FAB7977V | |
Alexa Fluor 488 | FAB7977G | |
Alexa Fluor 594 | FAB7977T | |
Alexa Fluor 647 | FAB7977R | |
Alexa Fluor 700 | FAB7977N | |
Alexa Fluor 750 | FAB7977S | |
Phycoerythrin | FAB7977P |
Diseases for GPR64 Antibody (FAB7977T)Discover more about diseases related to GPR64 Antibody (FAB7977T).
| Pathways for GPR64 Antibody (FAB7977T)View related products by pathway.
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PTMs for GPR64 Antibody (FAB7977T)Learn more about PTMs related to GPR64 Antibody (FAB7977T).
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