Exostosin-like 2/EXTL2 Antibody [Janelia Fluor® 525]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Janelia Fluor 525

Exostosin-like 2/EXTL2 Antibody [Janelia Fluor® 525] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Exostosin-like 2/EXTL2 Lumenal Domain
  Asn43-Met330
  Accession # Q9ES89
• Specificity: Detects mouse Exostosin-like 2/EXTL2 Lumenal Domain in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity with recombinant mouse EXTL1 and recombinant human EXTL3 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: EXTL2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Exostosin-like 2/EXTL2 Antibody [Janelia Fluor® 525]

• Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
• alpha-1,4-N-acteylhexosaminyltransferase
• Alpha-GalNAcT EXTL2
• EC 2.4.1.223
• exostoses (multiple)-like 2
• Exostosin like 2
• Exostosin-like 2
• EXTL2
• EXTR2
• EXT-related protein 2
• Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• processed exostosin-like 2

Background

Exostosin-like 2, or EXTL2 can be found in the extracellular region of the endoplasmic reticulum and is integral to the membrane. Belonging to the glycosyltransferase 47 family, EXTL2 encodes 4-N-acetylhexosamynyltransferase and transfers N-acetylglucosamine to the glycosaminoglycan (GAG) protein linkage region. More specifically, EXTL2 is critical for the synthesis of heparin/heparan sulfate, and the lack of EXTL2 can cause GAG overproduction. Biological processes associated with EXTL2 include the N-acetylglucosamine metabolic process, heparan sulfate proteoglycan biosynthetic process and UDP-N-acetylgalactosamine metabolic process. Known diseases for EXTL2 include Exostosis and hereditary multiple exostoses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EXTL2