DNAL1 Antibody

Images

 
Western Blot: DNAL1 Antibody [NBP1-76932] - 3T3 cell lysate with DNAL1 antibody at (A) 1 and (B) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: DNAL1 Antibody [NBP1-76932] - 3T3 cells with DNAL1 antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

DNAL1 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human DNAL1. The immunogen is located within the last 50 amino acids of DNAL1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DNAL1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Control Peptide
DNAL1 Peptide (NBP1-76932PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DNAL1 Antibody

  • C14orf168MGC12435,1700010H15RiK
  • chromosome 14 open reading frame 168
  • dynein light chain 1, axonemal
  • dynein, axonemal, light chain 1

Background

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional DNAL1 Products

DNAL1 NBP1-76932

Bioinformatics Tool for DNAL1 Antibody (NBP1-76932)

Discover related pathways, diseases and genes to DNAL1 Antibody (NBP1-76932). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for DNAL1 Antibody (NBP1-76932)

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Calculators

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Bioinformatics

Gene Symbol DNAL1
Uniprot