Desmoglein-4 Recombinant Protein Antigen

• Reactivity: Hu
• Applications: AC

Desmoglein-4 Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human Desmoglein-4
  
  

  Source: E.coli

  Amino Acid Sequence: PAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQ

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: DSG4
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10-100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP3-24786It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for Desmoglein-4 Recombinant Protein Antigen

• Cad13
• Cadherin family member 13
• CDGF13
• CDHF13
• CDHF13CDH family member 13
• desmoglein 4
• Desmoglein4
• Desmoglein-4
• DSG4
• LAHdesmoglein-4

Background

DSG4, also known as Desmoglein-4, consists of a 113.8 kDa and a 115.5 kDa isoform and is located in the membrane of desmosomes where it moderates cell to cell adhesion. Diseases and disorders such as impetigo, pemphigus foliaceus, skin disease, prostatitis, hypotrichosis, and monilethrix have been researched with this protein. The protein interacts with other proteins including RAB24, MLST8, and PKP3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DSG4