DAPP1 Antibody (716804) [Janelia Fluor® 669]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 716804
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

DAPP1 Antibody (716804) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human DAPP1
  Gly2-Ser163
  Accession # Q9UN19
• Specificity: Detects human DAPP1 in direct ELISAs. Detects human and mouse DAPP1 in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: DAPP1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DAPP1 Antibody (716804) [Janelia Fluor® 669]

• B lymphocyte adapter protein Bam32
• BAM32
• BAM32DKFZp667E0716
• B-cell adapter molecule of 32 kDa
• DAPP1
• dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
• dual adaptor of phosphotyrosine and 3-phosphoinositides
• hDAPP1

Background

B cell adapter molecule (BAM32) is also designated a dual adapter for phosphotyrosine and 3-phosphotyrosine, and 3-phosphoinositide (DAPP1) or B lymphocyte adapter protein. BAM32 is a B cell-associated adapter that is crucial for B cell antigen receptor signaling regulation. BAM32 interacts with Ptdlns and PLC gamma2 and, upon B cell activation, the protein is phosphorylated on tyrosine residues. It is a mainly cytoplasmic protein that can translocate to the cell membrane after cell stimulation. BAM32, which contains one PH domain and one SH2 domain, is primarily expressed in placenta and lung tissues, but can also be detected in heart, liver, pancreas and brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DAPP1