CEP290 Antibody

ELISA: CEP290 Antibody [44100002]

Product Discontinued

CEP290 Antibody Summary

• Immunogen: This antibody is specific for the C Terminus Region of the target protein.
• Specificity: This product is specific for Human CEP290.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CEP290
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:5000-1:20000
• Application Notes: This antibody is useful in ELISA and Western Blot.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for CEP290 Antibody

• BBS14Bardet-Biedl syndrome 14 protein
• Cancer/testis antigen 87
• centrosomal protein 290kDa
• Cep290
• CT87JBTS6
• FLJ13615
• JBTS5CTCL tumor antigen se2-2
• KIAA0373FLJ21979
• LCA10monoclonal 3H11 antigen
• MKS4
• Nephrocystin-6
• NPHP6centrosomal protein of 290 kDa
• POC3 centriolar protein homolog
• POC3
• prostate cancer antigen T21
• rd16,3H11AG
• SLSN6nephrocytsin-6,3H11Ag
• Tumor antigen se2-2

Background

This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CEP290 Antibody (44100002)(3)

Publications using 44100002

• Ott C, Nachmias D, Adar S, Jarnik M. VPS4 is a dynamic component of the centrosome that regulates centrosome localization of gamma-tubulin, centriolar satellite stability and ciliogenesis. Sci Rep. 2018-02-20 [PMID: 29463826] (WB)
• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: CEP290
• Entrez:
  • 80184(Human)
• Uniprot:
  • O15078(Human)