CD200R1L Antibody (2692A) [Alexa Fluor™ Plus 647]

• Clone: 2692A
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 647

CD200R1L Antibody (2692A) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects mouse CD200R1L in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD200R1L Antibody (2692A) [Alexa Fluor™ Plus 647]

• cell surface glycoprotein CD200 receptor 2
• CD200 receptor 1-like
• CD200R1L
• CD200R2
• CD200RLa

Background

CD200 Receptor 2 (CD200R2), or CD200R1L, is a type I transmembrane receptor for the CD200 cell surface glycoprotein. Mature CD200R2 consists of an extracellular domain (ECD) containing an Ig-like V-type domain and an Ig-like C2-type domain, a transmembrane segment and a short cytoplasmic domain. The ECD of mouse CD200R2 shares a 76% and 63% amino acid (aa) identity with the rat and human ECD, respectively. CD200R2 is strongly expressed on resting mast cells but deceased upon activation via Fc epsilon R1. It is also observed on monocytes, bone marrow-derived dendritic cells and TH2 cells (1, 2, 4). It has been demonstrated CD200R2 can interact with CD200 (3) and signal through adaptor protein, DAP12, via its lysine residue in the transmembrane region (2). In addition, it has been reported CD200 and CD200R2 interaction alters dendritic cell differentiation and enhances induction of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in mouse transplant model (5).

1. Wright, G. et al. (2003) J. Immunol. 171:3034.
2. Voehringer, D. (2004) J. Biol. Chem. 279(52):54117.
3. Gorczynski, R. et al. (2004) J. Immunol. 172:7744.
4. Minas, K. (2006) Crit Rev Immunol 26(3):213.
5. Gorczynski, R. et al. (2008) J. Immunol. 180(9):5946.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.