Recombinant Human CCDC88B GST (N-Term) Protein

12.5% SDS-PAGE Stained with Coomassie Blue.

Product Discontinued

Recombinant Human CCDC88B GST (N-Term) Protein Summary

• Description: A recombinant protein with GST tag at N-terminal corresponding to the amino acids 1-223 of Human CCDC88B
  
  

  Source: Wheat Germ (in vitro)

  Amino Acid Sequence: MRPWQAGSGGNSAQGSRWGEALSHSALGTPLGNDSDSAIQAPWGRPSPTAKDLVWDGRTPLRPCRNTKQMPTERALRYRNRRNVPSPHPSASDTVGTAGLGVQPSRHWSVSGGPRQPKSSGSQGPQGESLDKEAWALRSSTVSAGARRWSWDECVDRGDGWPPRAAPGWSSGSSRWLPLRQRSLGDPPAEGGWQELAREPPALSRWEAESQCWGTVAWADLEP

• Preparation Method: in vitro wheat germ expression system
• Details of Functionality: This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated.
• Source: Wheat germ
• Protein/Peptide Type: Recombinant Protein
• Gene: CCDC88B
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • Western Blot
• Theoretical MW: 50.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human CCDC88B GST (N-Term) Protein

• 78 kDa glucose-regulated protein GRP78-interacting protein induced by ER stress
• brain leucine zipper domain-containing protein
• brain leucine zipper protein
• CCDC88
• coiled-coil domain containing 88B
• coiled-coil domain-containing protein 88B
• gipie
• HKRP3
• hook-related protein 3

Background

CCDC88B, also known as Coiled-coil domain-containing protein 88B, has 6 isoforms, a 1476 amino acid isoform that is 165 kDa, a 1034 amino acid isoform that is 114 kDa, a 621 amino acid isoform that is 67 kDa, a 1358 amino acid isoform that is 151 kDa, 696 amino acid isoform that is 79 kDa, and a 139 amino acid isoform that is 15 kDa; and may be involved in linking organelles to microtubules. This protein has been associated with LPS-induced acute lung injury, cerulein induced chronic pancreatitis, Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome. CCDC88B interacts with PLEKHA5, PBX2, MAP3K7 and GRP78 in signaling pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: CCDC88B