beta-Arrestin 2 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: mFluor Violet 610 SE

beta-Arrestin 2 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: E. coli-derived recombinant human beta -Arrestin 2
  Met1-Cys409
  Accession # P32121
• Specificity: Detects human beta -Arrestin 2 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant human beta -Arrrestin 1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ARRB2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for beta-Arrestin 2 Antibody [mFluor Violet 610 SE]

• ARB2
• ARR2
• ARRB2
• arrestin 3
• Arrestin beta-2
• arrestin, beta 2
• BARR2
• betaArrestin 2
• beta-Arrestin 2
• beta-arrestin-2
• DKFZp686L0365

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ARRB2