beta-Arrestin 1 Antibody (425817) [FITC]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 425817
• Clonality: Monoclonal
• Host: Rat
• Conjugate: FITC

beta-Arrestin 1 Antibody (425817) [FITC] Summary

• Immunogen: E. coli-derived recombinant human beta -Arrestin 1
  Met1-Arg418
  Accession # P49407
• Specificity: Detects human beta -Arrestin 1 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ARRB1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for beta-Arrestin 1 Antibody (425817) [FITC]

• ARB1
• ARR1
• ARRB1
• arrestin 2
• Arrestin beta-1
• arrestin, beta 1
• betaArrestin 1
• beta-Arrestin 1
• beta-arrestin-1

Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization ofG-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in thebeta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the centralnervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin systemis believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcriptsencoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.(provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ARRB1