Beta 2 Adaptin Antibody

Western Blot: Beta 2 Adaptin Antibody [NB100-74371] - Analysis of bovine brain.

Product Discontinued

Beta 2 Adaptin Antibody Summary

• Immunogen: Synthetic peptide corresponding to residues I(588) H R K H L P I H H G S T D A G D S P(606) of human beta Adaptin 2.
• Specificity: beta-2 Adaptin
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AP2B1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Control:

  Beta 2 Adaptin Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Beta 2 Adaptin Antibody

• Adapter-related protein complex 2 beta subunit
• Adaptor protein complex AP-2 subunit beta
• adaptor-related protein complex 2, beta 1 subunit
• ADTB2adaptin, beta 2 (beta)
• AP105B
• AP2-BETA
• beta-2-adaptin
• beta-adaptin
• CLAPB1AP-2 complex subunit beta
• Clathrin assembly protein complex 2 beta large chain
• clathrin-associated/assembly/adaptor protein, large, beta 1
• DKFZp781K0743
• Plasma membrane adaptor HA2/AP2 adaptin beta subunit

Background

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AP2B1
• Entrez:
  • 163(Human)
  • 140670(Rat)