POT1 Products

Description

POT1 (protection of telomeres 1), a telomere regulator, is a single-stranded telomeric DNA-binding protein that controls telomerase-mediated telomere elongation. Telomere maintenance is required for protection against changes in telomere length, which has been implicated in ageing and certain cancers. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Excessive transcriptional expression of POT1 has been associated with stomach cancers.

Bioinformatics

Entrez	25913 Human
Uniprot	NM_015450 Human NP_056265 Human Q9NUX5 Human
Product By Gene ID	25913
Alternate Names	DKFZp586D211 HPOT1 hPot1 POT1 protection of telomeres 1 homolog POT1-like telomere end-binding protein protection of telomeres 1 homolog (S. pombe) protection of telomeres protein 1

Research Areas for POT1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Chromatin Research
DNA replication, Transcription, Translation and Splicing

Related POT1 Blog Posts

Check out the latest blog posts on POT1.

Application Highlight: Recent uses of TERF2 in immunofluorescence (IF) Telomeres are a region of repeat nucleotide sequences located at the end of chromosomes to protect our DNA from becoming damaged via end-to-end fusion.  TERF2, or telomeric-repeat binding factor 2, is important for telomere integrity and aids in th...    Read more.

Read more POT1 related blogs.