Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ELISA, Flow, GS, ICC/IF, IHC, IP, ChIP, Mycoplasma
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Pm
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
GADD153 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Bioinformatics
| Product By Gene ID |
1649 |
| Alternate Names |
- C/EBP-homologous protein 10
- C/EBP-homologous protein
- CCAAT/enhancer-binding protein homologous protein
- CEBP zeta
- CHOP
- CHOP10 CEBPZ
- CHOP10
- CHOP-10
- CHOPC/EBP zeta
- DDIT3
- DDIT-3
- DNA damage-inducible transcript 3 protein
- DNA-damage-inducible transcript 3
- GADD153
- Growth arrest and DNA damage-inducible protein GADD153
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