WB, Flow, IHC, CyTOF-readyHost:
Applications: Flow, Flow-CS
Host: Mouse Monoclonal
Applications: Binding Activity, Bioactivity
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM]
|Product By Gene ID
- TIM3 T-cell membrane protein 3
- TIM 3
- T cell immunoglobulin mucin-3
- T cell immunoglobulin mucin 3
- kidney injury molecule-3
- T-cell immunoglobulin and mucin domain-containing protein 3
- hepatitis A virus cellular receptor 2
Research Areas for TIM-3
Find related products by research area and learn more about each of the different research areas below.ImmunologyInnate Immunity
Bioinformatics Tool for TIM-3
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Related TIM-3 Blog Posts
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Read more TIM-3 related blogs.
|TIM-3, a critical immune checkpoint in HIV research
CD4+ T-helper cells (Th) are the white blood lymphocytes expressing surface glycoprotein antigen CD4. These T-helper cells play an important role in the adaptive immune system by releasing T cell cytokines that help other immune cells to suppress o... Read more.