PINK1 Products

Antibodies
PINK1 Antibody
PINK1 Antibody
NBP1-49678
Species: Hu, Mu
Applications: Simple Western, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PINK1 Antibody (8E10.1D6)
PINK1 Antibody (8E10.1D6)
NBP2-36488
Species: Hu, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
PINK1 Overexpression Lysate ( ...
PINK1 Overexpression Lysate (Denat...
H00065018-T02
Species: Hu
Applications: WB
Host: Human
PINK1 Overexpression Lysate ( ...
PINK1 Overexpression Lysate (Native)
NBP2-06032
Applications: WB
Host: HEK293
Proteins
PINK1 Peptide
PINK1 Peptide
NB100-493PEP
Species: Hu
PINK1 Peptide
PINK1 Peptide
BC100-494PEP
Species: Hu
Recombinant Human PINK1 Prote ...
Recombinant Human PINK1 Protein
H00065018-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PINK1 RNAi
PINK1 RNAi
H00065018-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

PTEN-induced putative kinase 1 (PINK1) is a mitochondrial serine/threonine protein kinase which is believed to protect cells from stress-induced mitochondrial degradation. PINK1 is also responsible for regulating degradation of damaged mitochondria via selective autophagy (mitophagy), and is required for PARK2 inidiated mitochondrial degradation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 65018
Alternate Names
  • Parkinson disease (autosomal recessive) 6
  • EC 2.7.11.1
  • PARK6
  • serine/threonine-protein kinase PINK1, mitochondrial
  • PTEN-induced putative kinase protein 1
  • protein kinase BRPK
  • BRPK
  • FLJ27236
  • PTEN induced putative kinase 1

Research Areas for PINK1

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
DNA Repair
Lipid and Metabolism
Mitochondrial Markers
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Protein Kinase
Signal Transduction

PTMs for PINK1

Learn more about PTMs related to PINK1.

Phosphorylation
Cleavage
Ubiquitination
Dephosphorylation
Oxidation

Bioinformatics Tool for PINK1

Discover related pathways, diseases and genes to PINK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related PINK1 Blog Posts

Check out the latest blog posts on PINK1.
The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...    Read more.
Parkin - Role in Mitochondrial Quality Control and Parkinson's Disease
Parkin/PARK2 is a cytosolic enzyme which gets recruited to cellular mitochondria damaged through depolarization, ROS or unfolded proteins accumulation, and exert protective effects by inducing mitophagy (mitochondrial autophagy). Parkin induces mit...    Read more.
PINK1 - performing mitochondrial quality control and protecting against Parkinson’s disease
PTEN-induced putative kinase 1 (PINK1) is a serine/threonine kinase with important functions in mitochondrial quality control. Together with the Parkin protein, PINK1 is able to regulate the selective degradation of damaged mitochondria through aut...    Read more.
PINK1: All work and no fun
The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.
PINK1 and its role in Parkinson's disease
PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondr...    Read more.
PINK1: Promoting Organelle Stability and Preventing Parkinson's disease
PINK1 is a protein serine/threonine kinase (PTK) that protects the organelles from cellular stress and controls selective autophagy to clear damage. Exner, et al. were among the first to report that PINK1 deficiency in humans was linked to autosomal r...    Read more.
PINK1: Promoting Organelle Stability and Preventing Parkinson's disease
PINK1 is a protein serine/threonine kinase (PTK) that protects the organelles from cellular stress and controls selective autophagy to clear damage. Exner, et. al. were among the first to report that PINK1 deficiency in humans was linked to autosomal...    Read more.
PINK1: Linking Mitochondrial Health and Parkinson's disease
Parkinson's disease is a degenerative disorder of the central nervous system, which involves the loss of dopaminergic neurons in the brain and gives rise to tremors, rigidity and slowness of movement. In the majority of cases there is no known cause;...    Read more.
PINK1: A Critical Player in Mitophagy
PINK1 (PTEN-induced putative kinase 1) is a mitochondrial directed serine-threonine kinase, that regulates normal mitochondrial function and transport vital to normal performance of neurons and neuronal survival. PINK1 has been shown to be localized t...    Read more.
Read more PINK1 related blogs.