Parkin Products

Antibodies
Parkin Antibody
Parkin Antibody
NB100-91921
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Parkin Antibody (1H4)
Parkin Antibody (1H4)
H00005071-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Parkin Antibody
Parkin Antibody
AF1438
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Antibody Pairs
Parkin Antibody Pair
Parkin Antibody Pair
H00005071-PW1
Species: Hu
Applications: WB, IP
Lysates
Parkin Overexpression Lysate ...
Parkin Overexpression Lysate (Dena...
H00005071-T01
Species: Hu
Applications: WB
Parkin Overexpression Lysate ...
Parkin Overexpression Lysate (Native)
NBL1-14105
Applications: WB
Proteins
Parkin Recombinant Protein
Parkin Recombinant Protein
H00005071-P01
Species: Hu
Applications: WB, ELISA, PA
Parkin Recombinant Protein
Parkin Recombinant Protein
NBP2-51533
Species: Hu
Applications: PAGE
Parkin Partial Recombinant Pr ...
Parkin Partial Recombinant Protein
H00005071-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Parkin RNAi
Parkin RNAi
H00005071-R01
Species: Hu
Applications: RNAi, RNAi SP
Parkin RNAi
Parkin RNAi
H00005071-R03
Species: Hu
Applications: RNAi, RNAi SP
Parkin RNAi
Parkin RNAi
H00005071-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 5071
Alternate Names
  • EC 6.3.2.-
  • LPRS2
  • parkin 2
  • Parkinson juvenile disease protein 2
  • E3 ubiquitin-protein ligase parkin
  • Parkinson disease protein 2
  • E3 ubiquitin ligase
  • PDJjuvenile) 2, parkin
  • parkin
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Research Areas for Parkin

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Phospho-Specific

PTMs for Parkin

Learn more about PTMs related to Parkin.

Ubiquitination
Phosphorylation
Methylation
Demethylation
Oxidation

Bioinformatics Tool for Parkin

Discover related pathways, diseases and genes to Parkin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Parkin Blog Posts

Check out the latest blog posts on Parkin.
Parkin - Role in Mitochondrial Quality Control and Parkinson's Disease
Parkin/PARK2 is a cytosolic enzyme which gets recruited to cellular mitochondria damaged through depolarization, ROS or unfolded proteins accumulation, and exert protective effects by inducing mitophagy (mitochondrial autophagy). Parkin induces mit...    Read more.
PINK1 - performing mitochondrial quality control and protecting against Parkinson’s disease
PTEN-induced putative kinase 1 (PINK1) is a serine/threonine kinase with important functions in mitochondrial quality control. Together with the Parkin protein, PINK1 is able to regulate the selective degradation of damaged mitochondria through aut...    Read more.
PINK1: All work and no fun
The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.
PINK1: Promoting Organelle Stability and Preventing Parkinson's disease
PINK1 is a protein serine/threonine kinase (PTK) that protects the organelles from cellular stress and controls selective autophagy to clear damage. Exner, et al. were among the first to report that PINK1 deficiency in humans was linked to autosomal r...    Read more.
Novus Antibodies Highlighted in Parkinson's Disease Research
Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide (www.parkinsons.org). The prevalence of Parkinson's disease is expected to grow considerably as the average age o...    Read more.
Read more Parkin related blogs.