PDE1B Products

Antibodies
PDE1B Antibody (5C4A3)
PDE1B Antibody (5C4A3)
NBP2-37404
Species: Hu, Rt
Applications: WB, ELISA, Flow, IHC, CyTOF-ready
Host: Mouse Monoclonal
PDE1B Antibody (6E4)
PDE1B Antibody (6E4)
NBP2-01063
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
PDE1B Antibody (10B10B12)
PDE1B Antibody (10B10B12)
NBP2-37403
Species: Hu, Mu, Pm
Applications: WB, ELISA, Flow, CyTOF-ready
Host: Mouse Monoclonal
Lysates
PDE1B Overexpression Lysate ( ...
PDE1B Overexpression Lysate (Native)
NBL1-14215
Applications: WB
Proteins
Recombinant Human PDE1B Prote ...
Recombinant Human PDE1B Protein
H00005153-Q01
Species: Hu
Applications: WB, ELISA, PA
PDE1B Recombinant Protein Ant ...
PDE1B Recombinant Protein Antigen
NBP1-80934PEP
Species: Hu
Applications: AC
RNAi
PDE1B RNAi
PDE1B RNAi
H00005153-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

PDE1B, a variant of PDE1, is a Ca2+-calmodulin-stimulated phosphodieterase (PDE) preferentially hydrolyzing cGMP. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, PDE1B, PDE1C). The enzymes of the PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. Calcium-Calmodulin stimulates the activity of each of these enzymes several-fold. The tissue distribution of PDE1B is different from other PDE1 gene family members. In testis PDE1B is expressed uniformly through out the seminiferous epithelium and in the interstistium in contrast to PDE1A and PDE1C that is expressed in elongated to mature spermatids.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 5153
Alternate Names
  • Phosphodiesterase-1B
  • EC 3.1.4
  • EC 3.1.4.17
  • presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase familyknown as PDE1B
  • 63 kDa Cam-PDE
  • phosphodiesterase IB, calmodulin-dependent
  • Cam-PDE 1B
  • PDES1Bcalmodulin-stimulated phosphodiesterase PDE1B1
  • PDE1B1calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
  • calcium/calmodulin-dependent 3'-5'-cyclic nucleotide phosphodiesterase 1B
  • phosphodiesterase 1B, calmodulin-dependent

Research Areas for PDE1B

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Signal Transduction

PTMs for PDE1B

Learn more about PTMs related to PDE1B.

Phosphorylation
Biotinylation
Phosphorothioation

Bioinformatics Tool for PDE1B

Discover related pathways, diseases and genes to PDE1B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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