PDE1B Products

Description

PDE1B, a variant of PDE1, is a Ca2+-calmodulin-stimulated phosphodieterase (PDE) preferentially hydrolyzing cGMP. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, PDE1B, PDE1C). The enzymes of the PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. Calcium-Calmodulin stimulates the activity of each of these enzymes several-fold. The tissue distribution of PDE1B is different from other PDE1 gene family members. In testis PDE1B is expressed uniformly through out the seminiferous epithelium and in the interstistium in contrast to PDE1A and PDE1C that is expressed in elongated to mature spermatids.

Bioinformatics

Uniprot	AAH32226 Human NM_000924 Human
Product By Gene ID	5153
Alternate Names	63 kDa Cam-PDE calcium/calmodulin-dependent 3'-5'-cyclic nucleotide phosphodiesterase 1B Cam-PDE 1B EC 3.1.4 EC 3.1.4.17 PDE1B1calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase PDES1Bcalmodulin-stimulated phosphodiesterase PDE1B1 phosphodiesterase 1B, calmodulin-dependent phosphodiesterase IB, calmodulin-dependent Phosphodiesterase-1B presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase familyknown as PDE1B

Research Areas for PDE1B

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Signal Transduction