p73 Products

Antibodies
p73 Antibody
p73 Antibody
NB100-420
Species: Hu, Primate, Monkey
Applications: WB, IHC, IHC-P, IP, PLA
Host: Rabbit Polyclonal
Lysates
p73 Overexpression Lysate (Na ...
p73 Overexpression Lysate (Native)
NBL1-17209
Applications: WB
RNAi
p73 RNAi
p73 RNAi
H00007161-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

p73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (alpha, beta, and gamma) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).

Bioinformatics

Uniprot Human
Human
Product By Gene ID 7161
Alternate Names
  • TAp73
  • TA p73
  • p53-related protein
  • P73p53-like transcription factor
  • tumor protein p73

Research Areas for p73

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

PTMs for p73

Learn more about PTMs related to p73.

Methylation
Phosphorylation
Demethylation
Reduction
Oxidation

Bioinformatics Tool for p73

Discover related pathways, diseases and genes to p73. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related p73 Blog Posts

Check out the latest blog posts on p73.
p73: An Important Tumor Suppressor Cousin of p53
p73 has been identified as a long-lost cousin of the p53 tumor suppressor protein. It has high homology with both p53 and with p63, a gene implicated in the maintenance of epithelial stem cells. The presence of significant homology between the DNA-bin...    Read more.
Read more p73 related blogs.