Hu, Mu, RtApplications:
WB, Simple Western, ChIP, Flow, ICC/IF, IHC-Fr, IHC-P, IP, CyTOF-readyHost:
WB, ChIP, ICC/IF, IHC, IPHost:
Hu, Mk, PmApplications:
WB, IHC, IHC-P, IP, PLAHost:
Applications: RNAi, RNAi SP
p73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (alpha, beta, and gamma) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).
|Product By Gene ID
- TA p73
- p53-related protein
- P73p53-like transcription factor
- tumor protein p73
Bioinformatics Tool for p73
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Related p73 Blog Posts
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|p73: An Important Tumor Suppressor Cousin of p53
p73 has been identified as a long-lost cousin of the p53 tumor suppressor protein. It has high homology with both p53 and with p63, a gene implicated in the maintenance of epithelial stem cells. The presence of significant homology between the DNA-bin... Read more.