NOD2 Products

Description

CARD15 (Nod2) is a member of the Nod1/Apaf-1 family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain. CARD15 induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It also confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Unlike Nod1, this homologue is primary expressed in monocytes. Defects in CARD15 are associated with Blau Syndrome (BS) and Crohn's Disease (CD), and are a cause of susceptibility to ulcerative colitis.

Bioinformatics

Entrez	64127 Human 257632 Mouse 291912 Rat
Uniprot	NP_071445.1 Human
Product By Gene ID	64127
Alternate Names	BLAU CARD15caspase recruitment domain protein 15 caspase recruitment domain family, member 15 Caspase recruitment domain-containing protein 15 CDACUG CLR16.3 IBD1NLR family, CARD domain containing 2 Inflammatory bowel disease protein 1 NLRC2 NOD-like receptor C2 nucleotide-binding oligomerization domain 2 nucleotide-binding oligomerization domain containing 2 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 2 nucleotide-binding oligomerization domain-containing protein 2 PSORAS1NOD2B

Research Areas for NOD2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy

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