NOD2 Products

Antibody Packs
NOD2 Antibody Pack
NOD2 Antibody Pack
Species: Hu
Applications: WB, IHC, IP
Host: Mouse
NOD2 Overexpression Lysate (N ...
NOD2 Overexpression Lysate (Native)
Applications: WB
NOD2 Peptide
NOD2 Peptide
Species: Hu
NOD2 Recombinant Protein Anti ...
NOD2 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl


NOD2 (nucleotide-binding oligomerization domain containing 2) is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB. It also acts as an intracellular receptor for bacterial lipopolysaccharides and contributes to inflammatory bowel disease (IBD) and Crohn's disease.


Uniprot Human
Product By Gene ID 64127
Alternate Names
  • Caspase recruitment domain-containing protein 15
  • nucleotide-binding oligomerization domain-containing protein 2
  • caspase recruitment domain family, member 15
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 2
  • NLRC2
  • nucleotide-binding oligomerization domain 2
  • CLR16.3
  • NOD-like receptor C2
  • BLAU
  • IBD1NLR family, CARD domain containing 2
  • CARD15caspase recruitment domain protein 15
  • Inflammatory bowel disease protein 1
  • nucleotide-binding oligomerization domain containing 2

Research Areas for NOD2

Find related products by research area and learn more about each of the different research areas below.

Cell Biology

Bioinformatics Tool for NOD2

Discover related pathways, diseases and genes to NOD2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related NOD2 Blog Posts

Check out the latest blog posts on NOD2.
Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...    Read more.
MHC Class I and the Herpes Simplex Virus
MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...    Read more.
CD3 (OKT3) as a marker of immune response efficiency
Our immune system is a powerful defense mechanism against infection, however different variables can cause our immune response to work for or against us.  CD3 (cluster of differentiation 3) is one component of our immune signal response that is co...    Read more.
NOD2 - inflammatory signaling and NFkB activation
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) that plays an important role in recognizing bacterial pathogens and initiating an immune response. As a PRR, NOD2 recogniz...    Read more.
Read more NOD2 related blogs.