MMR/CD206/Mannose Receptor Products

Description

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

Bioinformatics

Product By Gene ID	4360
Alternate Names	CD206 CLEC13D CLEC13Dmacrophage mannose receptor 1 C-type lectin domain family 13 member D mannose receptor, C type 1 MMR MMRCD206 antigen MRC1

Research Areas for MMR/CD206/Mannose Receptor

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Signal Transduction

Related MMR/CD206/Mannose Receptor Blog Posts

Check out the latest blog posts on MMR/CD206/Mannose Receptor.

Read more.

Read more MMR/CD206/Mannose Receptor related blogs.