Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Ca
Applications: WB, Flow, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB, Flow
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Host: Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Hu
Applications: Binding Activity
Species: Pm-Cm
Applications: Bioactivity
Description
IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
3563 |
| Alternate Names |
- CD123 antigen
- CD123
- hIL3Ra
- hIL-3Ra
- IL-3 receptor subunit alpha
- IL-3R subunit alpha
- IL3R
- IL-3RA
- IL-3R-alpha
- IL3RAY
- IL3RX
- IL3RY
- interleukin 3 receptor, alpha (low affinity)
- interleukin-3 receptor subunit alpha
- MGC34174
|
Research Areas for IL-3R alpha/CD123
Find related products by research area and learn more about each of the different research areas below.
Cytokine ResearchPhospho-Specific
![Immunocytochemistry IL-3R alpha/CD123 Antibody (32703) [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_MAB301_Immunocytochemistry_6602.jpg)
![Sandwich ELISA IL-3R alpha/CD123 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-3R-alpha-CD123-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79483-img0001.jpg)
![Binding Activity IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_301-R3_CF_581.jpg)
![Binding Activity IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_301-R3_580.jpg)
![Binding Activity IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize/protein/10597-r3_recombinant-cynomolgus-monkey-il-3r-alpha-fc-protein-cf-binding-activity-1792020101317.jpg)
![Immunohistochemistry IL-3R alpha/CD123 Antibody (32703) [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_MAB301_Immunohistochemistry_6988.jpg)
![Neutralization IL-3R alpha/CD123 Antibody (32703) [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_MAB301_Block_Neutralize_2301.jpg)
![Flow Cytometry IL-3R alpha/CD123 Antibody (32703) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab301_human-il-3-r-alpha-cd123-mab-clone-32703-flow-cytometry-512024183146.jpg)
![SDS-PAGE IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_301-R3_CF_579.jpg)
![SDS-PAGE IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize2/IL-3_R_alpha_301-R3_578.jpg)
![SDS-PAGE IL-3R alpha/CD123 [Unconjugated]](http://images.novusbio.com/fullsize/protein/10597-r3_recombinant-cynomolgus-monkey-il-3r-alpha-fc-protein-cf-sds-page-492020115517.jpg)