IL-12/IL-35 p35 Products

Description

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Bioinformatics

Product By Gene ID

3592

Alternate Names

CLMF p35 CLMF cytotoxic lymphocyte maturation factor 1, p35 Cytotoxic lymphocyte maturation factor 35 kDa subunit IL-12, subunit p35 IL-12A IL35 subunit interleukin 12, p35 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) interleukin-12 alpha chain interleukin-12 subunit alpha NF cell stimulatory factor chain 1 NFSK NK cell stimulatory factor chain 1 NKSF1 p35