GADD153/CHOP Products

Description

GADD153 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Bioinformatics

Entrez	1649 Human 3553 Human 13198 Mouse 29467 Rat
Uniprot	NM_004083 Human AAH03637 Human AAH03637.1 Human P35638 Human NP_004074 Human P01584 Human P35639 Mouse
Product By Gene ID	1649
Alternate Names	C/EBP-homologous protein CHOP-10 DNA damage-inducible transcript 3 protein Growth arrest and DNA damage-inducible protein GADD153 CCAAT/enhancer-binding protein homologous protein C/EBP-homologous protein 10 CHOPC/EBP zeta GADD153 CHOP10 CEBPZ DDIT-3 DNA-damage-inducible transcript 3

Diseases related to GADD153/CHOP

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Endoplasmic Reticulum Stress
Malignant Neoplasms
Neoplasms
Growth Arrest
Physiological Stress
Carcinoma
Liposarcoma
Liposarcoma, Myxoid
Diabetes Mellitus
Malignant Paraganglionic Neoplasm
Leukemia
Liver Carcinoma
Chromosomal Translocation
Inflammation
Mammary Neoplasms
Sarcoma
Feline Urological Syndrome
Hypoxia
Malignant Neoplasm Of Breast

Pathways for GADD153/CHOP

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Cell Death
Cell Cycle
Translation
Pathogenesis
Cell Growth
Cell Proliferation
Induction Of Apoptosis
Cell Cycle Arrest
Localization
Secretion
Autophagy
Dna Repair
Transport
Rna Interference
Response To Stress
Cell Differentiation
S Phase
Programmed Cell Death
Gene Silencing
Insulin Secretion

Research Areas for GADD153/CHOP

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Apoptosis
Cell Cycle and Replication
DNA Repair
Hypoxia
Lipid and Metabolism
Neuroscience
Unfolded Protein Response

PTMs for GADD153/CHOP

Learn more about PTMs related to GADD153/CHOP.

Phosphorylation
Cleavage
Dephosphorylation
Ubiquitination
Methylation
Glycosylation
Oxidation
Reduction
Acetylation
Deacetylation
Carboxylation
Phosphorothionation
Prenylation
Farnesylation
Myristoylation

Bioinformatics Tool for GADD153/CHOP

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