Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ELISA, Flow, GS, ICC/IF, IHC, IHC-P, IP, ChIP, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Pm
Applications: WB, Flow, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IHC-P
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
GADD153 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Bioinformatics
Entrez |
Human Human Mouse Rat |
Uniprot |
Human Human Human Human Human Human Mouse |
Product By Gene ID |
1649 |
Alternate Names |
- C/EBP-homologous protein
- CHOP-10
- DNA damage-inducible transcript 3 protein
- Growth arrest and DNA damage-inducible protein GADD153
- CCAAT/enhancer-binding protein homologous protein
- C/EBP-homologous protein 10
- CHOPC/EBP zeta
- GADD153
- CHOP10 CEBPZ
- DDIT-3
- DNA-damage-inducible transcript 3
|
Bioinformatics Tool for GADD153/CHOP
Discover related pathways, diseases and genes to GADD153/CHOP. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.