Endoglin/CD105 Products

Description

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Bioinformatics

Entrez	13805 Mouse 2022 Human
Uniprot	AAH14271 Human AAH14271.1 Human NM_000118 Human P17813 Human Q5T9B9 Human
Product By Gene ID	2022
Alternate Names	CD105 antigen CD105 endoglin ENDOsler-Rendu-Weber syndrome 1 HHT1FLJ41744 ORW ORW1

Research Areas for Endoglin/CD105

Find related products by research area and learn more about each of the different research areas below.

Cancer
CD Markers
Cell Biology
Cellular Markers
Endothelial Cell Markers
Extracellular Matrix
Hypoxia
Immunology
Mesenchymal Stem Cell Markers
Stem Cell Markers