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5036-WN) induces a dose responsive increase in Wnt reporter activity in HEK293 cells (green circles). Recombinant Human Dkk-4 (Catalog # 1269-DK) inhibits a constant dose of 500 ng/mL of Recombinant Human Wnt-3a. The ED50 for this effect is 150-900 ng/mL (orange circles)." class="big_lightbox" target="_blank">
1324-WN) induces a dose responsive increase in Wnt reporter activity in HEK293 cells (green circles). Recombinant Mouse Dkk-4 (Catalog # 3105-DK) inhibits a constant dose of 100 ng/mL of Recombinant Mouse Wnt-3a. The ED50 for this effect is 0.2-1.2 µg/mL (orange circles)." class="big_lightbox" target="_blank">
DKK4 is a secreted protein that is a member of the dickkopf family. Like some other members of the dickkopf family DKK4 contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The activity of DKK4 is modulated by binding to the Wnt co-receptor and the co-factor kremen 2, and it is proposed that it is also an inhibitor of the Wnt signaling pathway.
![Bioactivity Dkk-4 [Unconjugated]](http://images.novusbio.com/images/protein/Dkk4_1269DK_1667.jpg)
![Bioactivity Dkk-4 [Unconjugated]](http://images.novusbio.com/images/protein/Dkk4_3105DK_1673.jpg)
