After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.
DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac
![Western Blot DARPP-32 Antibody (375604) [Unconjugated]](http://images.novusbio.com/fullsize2/DARPP-32_MAB4230_Western_Blot_6161.jpg)
![Western Blot DARPP-32 [p Thr75] Antibody - Azide Free](http://images.novusbio.com/fullsize/DARPP32-[p-Thr75]-Antibody-Western-Blot-NB300-234-img0003.jpg)
![Western Blot DARPP-32 [p Thr75] Antibody - Azide Free](http://images.novusbio.com/fullsize/DARPP32-[p-Thr75]-Antibody-Western-Blot-NB300-234-img0002.jpg)
