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295-OM) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Oncostatin M/OSM (0.8 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human gp130 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-228-NA). The ND50 is typically 2-10 µg/mL." class="big_lightbox" target="_blank">
HAF017). A specific band was detected for gp130 at approximately 150kDa kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1." class="big_lightbox" target="_blank">
CTS013). Tissue was stained using the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (brown; Catalog # VC001) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in exocrine cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
AR002). Proliferation elicited by Recombinant Human Oncostatin M/OSM (0.8 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human gp130 Monoclonal Antibody (Catalog # MAB628). The ND50 is typically 0.02-0.1 µg/mL." class="big_lightbox" target="_blank">
CD130 is encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
![Neutralization gp130/CD130 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/gp130_AF-228-NA_Block_Neutralize_8658.jpg)
![Flow Cytometry gp130/CD130 Antibody (125623) [Unconjugated]](http://images.novusbio.com/images/antibody/gp130_MAB4681_Flow_Cytometry_19594.jpg)
![Immunohistochemistry gp130/CD130 Antibody (28105) [Unconjugated]](http://images.novusbio.com/images/antibody/gp130_MAB628_Immunohistochemistry_24143.jpg)
![Sandwich ELISA gp130/CD130 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/gp130-CD130-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79535-img0001.jpg)
![N/A gp130/CD130 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_gp130_DGP00_ELISA_705.jpg)
![N/A gp130/CD130 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_gp130_DY228_ELISA_1804.jpg)
![N/A gp130/CD130 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_gp130_DY468_ELISA_2049.jpg)
![Western Blot gp130/CD130 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/af-228-na_human-gp130-affinity-purified-polyclonal-ab-western-blot-2032023143840.jpg)
![Western Blot gp130/CD130 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af-228-na_human-gp130-affinity-purified-polyclonal-ab-western-blot-121220259313324.jpg)
![Immunocytochemistry gp130/CD130 Antibody (125623) [Unconjugated]](http://images.novusbio.com/images/antibody/gp130_MAB4681_Immunocytochemistry_6619.jpg)
![Immunohistochemistry gp130/CD130 Antibody (125623) [Unconjugated]](http://images.novusbio.com/fullsize/mab4681_mouse-gp130-mab-clone-125623-41202412512651.jpg)
![Neutralization gp130/CD130 Antibody (28105) [Unconjugated]](http://images.novusbio.com/images/antibody/gp130_MAB628_Block_Neutralize_9247.jpg)
![N/A gp130/CD130 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_gp130_DGP00_ELISA_706.jpg)
![N/A gp130/CD130 [HRP]](http://images.novusbio.com/fullsize/elisa/gp130_DGP00_ELISA_111.jpg)
![Bioactivity gp130/CD130 [Unconjugated]](http://images.novusbio.com/images/protein/gp130_468MG_2266.jpg)
