MeCP2 Products

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Bioinformatics

Entrez	17257 Mouse 29386 Rat 4204 Human
Uniprot	AAH11612 Human NM_004992 Human NP_004983.1 Human P51608 (human) Human P51608 Human
Product By Gene ID	4204
Alternate Names	AUTSX3 DKFZp686A24160 MeCp-2 protein mental retardation, X-linked 79 methyl CpG binding protein 2 (Rett syndrome) X-linked 16

Research Areas for MeCP2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Neuroscience
Phospho-Specific

Related MeCP2 Blog Posts

Check out the latest blog posts on MeCP2.

New MECP2 Study Suggests Important Link to GABA MECP2 antibodies are used in DNA methylation studies as well as research into Rett syndrome, a progressive neurological disorder caused by a mutation in the MECP2 gene. Now, a new study has been published by the laboratory where the Rett Syndrome gene...    Read more.

Read more MeCP2 related blogs.