Cancer

A large number of antibody assays are devoted to the study of nuclear excision repair (NER) proteins. However, there are a number of other DNA repair pathways, many of which are instigated by NER and share the same proteins. DNA repair antibodies are widely used in cancer research, and Novus Biologicals offers an extensive selection of thoroughly validated, high-quality DNA repair and cancer related antibodies.

Our antibody database at Novus Biologicals provides research tools for the forefront of cancer research. Recently, a mouse study using 53BP1 and BRCA1 antibodies showed that deletion of 53BP1 greatly lessened the incidence of tumor development in mice carrying the mutated BRCA1 gene.

PCNA antibodies are useful biomarkers in DNA repair studies. PCNA is one of several proteins essential for the completion of nucleotide excision repair, a multi-stage process involving 20 - 30 proteins, and an important factor in repairing damage and mutations to the DNA helical structure.

We at Novus Biologicals have over 230 products in our antibody catalog devoted to nucleotide excision repair. NER is a multi-stage sequential process involving over 30 proteins, all of which have been widely studied. Being the primary method to repair DNA damage caused by agents ranging from UV radiation to chemotherapy drugs, our NER antibody database is widely used by cancer research groups.

The mammalian DNA repair process encompasses a large number of protein pathways, and forms an important part of our antibody catalog. The past 30 years have seen tremendous advances in the understanding of these mechanisms, with Wood, et al. recently compiling an updated inventory of at least 150 human DNA-repair proteins. This added considerably to the scope of the antibody database of us at Novus Biologicals.

Novus Biologicals specializes in offering top quality antibody reagents to many of the transcription factor proteins that are widely expressed in cancer cells.

We at Novus Biologicals are constantly updating our antibody catalog in order to provide as comprehensive a database as possible for molecular biology researchers. Not all our antibodies are derived from proteins found in mammalian or human tissue. Some are derived from single-celled or non-eucaryotic organisms which produce harmful effects when introduced to humans or animals.

We at Novus Biologicals are one of the leading antibody suppliers for diabetes research. An aging population, and the increasing incidence of type 2 diabetes, makes it an area of increasing interest - especially as there is often a close link to cancer. Metabolic studies and diabetes research go hand-in-hand.

We at Novus Biologicals are one of the leading antibody suppliers for products targeted to apoptosis. These products are regularly used by cancer research groups - apoptosis is fundamental to developing therapies that will kill tumor cells. Caspase proteins, which play a key role in apoptosis, are therefore regularly featured in our antibody catalog.

We at Novus Biologicals recently added two new MCP1 antibodies to our antibody catalog. MCP1, also known as MCAF (monocyte chemotactic and activating factor) is released by a diverse range of cell types as part of the inflammatory response. A member of the SIG (small inducible gene) family, it is selective for monocytes and basophils, mainly to recruit monocytes to injury and infection sites.