Amish Genetic Purity Shown to be Ideal for In Vitro Metabolic Research

Wed, 04/14/2010 - 03:25


Human derived antibodies are widely used in disease research. These tend to be associated with cancer cell lines, such as the MCF7 breast tumour line, for which we provide both antibodies and whole cell lysate. The cells that are generated are identical in every respect to the originals, meaning reproducible results can be obtained years after the original cell lines were harvested.

When it comes to in vivo studies, however, it is generally accepted that genetically similar results are only obtainable from genetically homogenous laboratory strains (Zucker rats, ob-ob mice etc.) The idea of a genetically homogenous human strain would seem to be unfeasible, but one does, in fact, exist, in the Old Order Amish people of North America.

The Amish are a pure-bred race who can trace their ancestry back to a small group of 18th century Europeans. Their mode of living has remained remarkably unchanged since then, giving them a degree of genetic purity that is on par with a laboratory animal model, and means comparable antibody results can be obtained from a number of individuals.

The University of Maryland has been using Amish volunteers since the 1990s to investigate human clinical conditions such as diabetes, heart disease and obesity. A recent study, published in 2008, looked at the effect of increased activity on the FTO 'fat' gene. Despite their active lifestyle, Amish people are as obese as other Caucasian Americans.

Western Blot: FTO Antibody Western Blot: FTO Antibody

The products we at Novus Biologicals have on our antibody database are mainly used for human research. The Maryland Amish data forms a unique contribution to this.

Novus Biologicals offers many FTO reagents for your research needs including:

 

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