CXCL8/IL-8 Products

Description

IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.

Bioinformatics

Entrez	3576 Human
Uniprot	AAH13615 Human AAH13615.1 Human NM_000584 Human NP_000575 Human P10145 Human
Product By Gene ID	3576
Alternate Names	3-10C AMCF-I C-X-C motif chemokine 8 CXCL8SCYB8 Emoctakin GCP-1TSG-1 interleukin 8 K60 LECT MDNCFb-ENAP member 8 MONAPGCP1 NAP-1NAP1 Neutrophil-activating protein 1 Protein 3-10C T cell chemotactic factor T-cell chemotactic factor

Research Areas for CXCL8/IL-8

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cytokine Research
Immunology
Innate Immunity
Signal Transduction

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