TNF RII/TNFRSF1B Products

Description

Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.

Bioinformatics

Entrez	21938 Mouse 7133 Human
Uniprot	AAH52977 Human NM_001066 Human NP_001057 Human NP_001057.1 Human P20333 Human
Product By Gene ID	7133
Alternate Names	CD120b antigen CD120b Etanercept p75 TNF receptor p75TBPII p75TNFR soluble TNFR1B variant 1 TNFBRp80 TNF-alpha receptor TNF-R2 TNFR2TNFR1B TNF-R75 TNFR80 TNF-RII TNF-R-II TNFR-II tumor necrosis factor beta receptor tumor necrosis factor binding protein 2 Tumor necrosis factor receptor 2 tumor necrosis factor receptor superfamily member 1B tumor necrosis factor receptor superfamily, member 1B Tumor necrosis factor receptor type II

Research Areas for TNF RII/TNFRSF1B

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