Vang-like Protein 1/VANGL1 Antibody (497707) [Alexa Fluor® 532]

• Applications: WB, ICC/IF
• Clone: 497707
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Vang-like Protein 1/VANGL1 Antibody (497707) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human Vang-like Protein 1/VANGL1
  Glu242-Val524
  Accession # Q8TAA9
• Specificity: Detects human Vang-like Protein 1/VANGL1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, slight cross-reactivity with recombinant human VANGL2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Human Van Gogh-like protein 1 (VANGL1; also Vang-like Protein 1, strabismus 2, loop tail protein 2 homolog, LPP2) is a 60 kDa (predicted) member of the Vang family of proteins. VANGL1 is 524 amino acids (aa) in length and contains four transmembrane regions and the C-terminal Ser/Thr-X-Val motif, but lacks a signal sequence. There are two isoforms for VANGL1. In isoform 2, residues 67-68 found in isoform 1 are deleted. Human VANGL1 shares 95% aa sequence identity with mouse VANGL1. The glycoprotein is ubiquitously expressed in normal tissues and is upregulated in many cancer cell lines. VANGL1 is predicted to be a tumor suppressor gene. Mutations in VANGL1 are associated with neural tube defects.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.