UNC13B Antibody (584102) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 584102
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

UNC13B Antibody (584102) [Alexa Fluor® 594] Summary

• Immunogen: E. Coli-derived recombinant human UNC13B
  Asp418-Ser1591
  Accession # O14795
• Specificity: Detects human UNC13B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) UNC13A and rhUNC13C is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for UNC13B Antibody (584102) [Alexa Fluor® 594]

• hmunc13
• homolog of rat Munc13 (diacylglycerol-binding)
• MGC133279
• MGC133280
• munc13
• Munc13-2
• MUNC13B
• protein unc-13 homolog B
• unc-13 homolog B (C. elegans)
• UNC13B
• Unc13h2
• unc-13-like (C. elegans)
• UNC13Unc13h2

Background

UNC13B is a 170 kDa member of the unc13 family. It is 1591 amino acids (aa) in length and contains three C2 domains, one MHD1 domain, one MHD2 domain, and one phorbol-ester/DAG-type zinc finger. Human UNC13B is 95% and 93% aa identical to mouse and rat UNC13B, respectively. UNC13B is expressed in brain and kidney cortical epithelial and mesangial cells. UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). In addition, UNC13B may be involved in mediating some of the acute and chronic changes in mesangial cells produced by exposure to hyperglycemia

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.