UNC13B Products

Description

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Bioinformatics

Entrez	10497 Human
Uniprot	NP_006368 Human
Product By Gene ID	10497
Alternate Names	hmunc13 homolog of rat Munc13 (diacylglycerol-binding) MGC133279 MGC133280 MUNC13 munc13-2 MUNC13B protein unc-13 homolog B unc-13 homolog B (C. elegans) UNC13B Unc13h2 unc-13-like (C. elegans) UNC13Unc13h2

Research Areas for UNC13B

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Apoptosis