Protocadherin-1 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Host: Goat
• Conjugate: Alexa Fluor 750

Protocadherin-1 Antibody [Alexa Fluor® 750] Summary

• Specificity: Detects human Protocadherin-1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Protocadherin-8 and rhProtocadherin-10 is observed.
• Isotype: IgG
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Protocadherin-1 Antibody [Alexa Fluor® 750]

• cadherin-like 1
• Cadherin-like protein 1
• FLJ53887
• MGC45991
• PC42
• PC42PCDH42
• PCDH1
• PCDH42
• protocadherin 1 (cadherin-like 1)
• protocadherin 1
• protocadherin 42
• Protocadherin1
• Protocadherin-1
• protocadherin-42

Background

Protocadherin-1 (PCDH-1; also PC42) is a 150 - 170 kDa δ1 subgroup member of the nonclustered protocadherin family of molecules. It is expressed on macrophages, respiratory epithelium, endothelial cells and neurons. Protocadherin-1 apparently forms homophilic Ca⁺⁺-dependent complexes and likely serves as an adhesion molecule. Human full-length Protocadherin-1 precursor is 1237 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains a 795 aa extracellular domain (ECD) (aa 58 - 852) plus a 364 aa cytoplasmic region. There are seven cadherin domains in the ECD (aa 58 - 844), and an RRVTF cytoplasmic motif that binds PP1 alpha phosphatase. There are multiple splice variants. Alternative start sites exist at Met23 and Met235, there is a deletion of aa 209 - 220, and a 27 aa substitution for aa 1034 - 1237. Over aa 58 - 162, human Protocadherin-1 shares 96% aa identity with mouse Protocadherin-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.